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pentobarbital will decrease the level or result of repaglinide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
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pentobarbital will decrease the level or result of levoketoconazole by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Unknown.
pentobarbital will decrease the level or impact of buprenorphine, lengthy-performing injection by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Closely. Sufferers who transfer to buprenorphine extended-acting injection from transmucosal buprenorphine coadministered with CYP3A4 inducers must be monitored to ensure buprenorphine plasma stages are satisfactory.
pentobarbital will lessen the level or result of stiripentol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. If not able to avoid coadministration of stiripentol with robust CYP3A4 inducers, maximize stiripentol dose.
pentobarbital will lower the extent or outcome of hydrocortisone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
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pentobarbital will lessen the extent or influence of lonafarnib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lonafarnib is a delicate CYP3A4 substrate. Coadministration with robust or reasonable CYP3A4 inducers is contraindicated.
pentobarbital will reduce the level or effect of dexamethasone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
Phenobarbital sodium is carcinogenic in mice and rats just after life time administration. In mice, it manufactured benign and malignant liver cell tumors. In rats, benign liver mobile tumors had been noticed extremely late in everyday life.
pentobarbital boosts toxicity of ifosfamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. CYP3A4 inducers might raise the metabolism of ifosfamide to its Energetic alkylating metabolites.
fentanyl transdermal and pentobarbital both enhance sedation. Keep away from or Use Alternate Drug. Limit use to sufferers for whom substitute remedy choices are inadequate
pentobarbital will lessen the level or here influence of lorlatinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will minimize the extent or outcome of paclitaxel protein sure by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unknown.